Effer-Soda®

$0.00

Product Application: Effervescent Tablet,Lozenge,Orally Dispersible Powder (ODP),Orally dissolving tablets,Soft Chews,Tablet
Pharmaceutical Category: Nutraceutical,Pharmaceutical

Effer-Soda® quantity

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Effer-Soda is a highly stable, surface-modified sodium bicarbonate powder developed for use in pharmaceutical and nutraceutical applications. Particles are surfaced modified with sodium carbonate to act as a protectant layer. It increases resistance to humidity and prevents premature effervescence, helping formulators to develop stable effervescent formulations regardless of packing forms. Products formulated with Effer-Soda require fewer binders. The is ideal application is effervescent tablets.

The Effer-Soda manufacturing process ensures that each particle of Sodium Bicarbonate is surface modified with Sodium Carbonate. Each particle must be surface modified to prevent contact of water or hydrated acid with the sodium bicarbonate, in order to avoid premature effervescence in both effervescent tablets and effervescent sachets.

Benefits at a Glance: 

• Particles are surfaced modified with sodium carbonate to act as a protectant layer
• Increases resistance to humidity and prevents premature effervescence
• Lower failure rate
• Microenvironmental pH modification improves the release of weakly acidic drugs
• Quick effervescence is possible when desired
• ~200 PSD D50 (μm)

Formulation Protection Testing

10g samples placed in sachets;  Conditions:

• 54% Sodium carbonate, Effer- Soda, or Sodium bicarbonate
• 46% Citric acid monohydrate
• Heated to 45-50 °C

2 Hours Later – Packaging checked for ballooning, you can see there is significant ballooning in the package formulated with sodium bicarbonate alone.

Compactibility Test

70% Effer-Soda, Sodium carbonate or Sodium bicarbonate; 30% Mannogem EZ; Compacted to 10, 20, and 30 kN; 1000mg tablets compressed using 0.625” FFBE “D” punch on Lloyds Press

 

Starting Point Effervescent Formulation for increased stability