LubriTose Mannitol

$0.00

Spray Dried Manntiol, Glyceryl Monostearate

Product Application: Direct tableting,Lubricant,Roller compaction
Product Certification: Gluten-free
Pharmaceutical Category: Self Lubricating Excipient,Tableting System
Download TDSDownload Product Brochure

LubriTose Mannitol is a co-processed excipient consisting of USP compliant Spray Dried Mannitol and NF/JP compliant Glyceryl Monostearate. It is meant to be used in standard direct tabletting applications or roller compaction. It is only necessary to add the API (active pharmaceutical ingredient), any other desired ingredient, and proceed to tabletting. The Glyceryl Monostearate is co-processed in to act as a lubricant and therefore it is not necessary to add a lubricant such as Magnesium Stearate to the tabletting formulation. By using LubriTose Mannitol, you get a true direct tabletting operation as the lubricant addition step is removed. LubriTose is ideal for continuous systems and also for QbD.

Mannitol is a commonly used excipient when used in an oral solid dose. It can provide non-cariogenic, and pleasant organoleptic properties to many chewable or ODT dose forms. The spray dried version of mannitol in particular offers the OSD formulator some very useful benefits when used in a direct compression manufacturing environment, due to its chemical stability and good flow properties.

Kerry introduced its LubriTose™ line of excipients that utilize a proprietary co-processing technique to incorporate GMS (Glyceryl Monostearate) in to the base excipient (typically Lactose, Microcrystalline Cellulose, or Mannitol) that essentially enables the entire formulation to become self lubricating, when used in combination with some API’s.

Evaluation of LubriTose Mannitol

Lubrication Evaluation: As previously demonstrated in other research, the lubrication properties of the tablet as measured by the ejection force showed that the lubrication properties of the LubriTose Mannitol were the same as those using Spray Dried Mannitol with the addition of 1% magnesium stearate as external lubricant.

LubriTose Mannitol vs. Mannitol/Magnesium Stearate

Compression Evaluation: The compression profile of LubriTose Mannitol was also shown to be superior to Spray Dried Mannitol. Even when comparing neat LubriTose™ Mannitol to 50/50 blends of Spray Dried Mannitol together with Microscrystalline Cellulose, the compression forces were similar.

*For full study, please download product brochure

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