Mannogem® Mannitols (Powder, Granular, 2080 & EZ) are manufactured to increase productivity, improve formulations for better tableting leading to overall improved patient experience. With multiple grades you can improve the patient experience and benefit from efficient manufacturing operations.
Mannogem® Mannitols
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Product Application: Chewable Tablet,DC Tablet,Sachet,TabletPharmaceutical Category: Binder,Excipient,Nutraceutical,Pharmaceutical
Mannogem® Mannitols are manufactured to increase productivity, improve formulations for better tableting for overall improved patient experience. With multiple grades you can improve the patient experience and benefit from efficient manufacturing operations by formulating with Mannogem Mannitol. Take a look at each grade to determine the best solution for your application:
Mannogem Powder
Mannogem Mannitol Powder is an excellent excipient for use in wet granulation and lyophilization. It dries rapidly, resulting in shorter processing time and increased productivity. A good excipient for hot melt extrusion applications. It melts without decomposition at a temperature of approximately 165° C. Its rapid recrystallization upon cooling makes it an attractive carrier to improve the solubility of poorly soluble APIs. Applicable in
- Liquid suspensions/syrups
- Wet granulation process
- Lyophilization process
- Hot-melt extrusion process
Mannogem Granular & Mannogem 2080
Granular Mannogem Grades are manufactured through a wet granulation process and have a larger particle size than our Mannogem spray-dried material. They exhibit excellent flow, disintegration, and compression properties. These products are ideal for formulating tablets with taste-masked APIs, which often have a larger particle size due to the taste-masking process. Both granular grades are applicable in:
- Dry blending
- Direct compression
- Roller compaction
Mannogem Granular has a larger particle size that has shown to contribute to a softer texture for chewable tablets. The larger particle size allows it to match specific particle size and density constraints to minimize segregation during transport and manufacturing. It is also the coarsest material, making for excellent flow and to match PSD to coarser actives. Allows for good content uniformity even in the presence of taste-masked API’s, MUP’s, etc. Excellent choice for stick packs & sachets, tablets, chewables & lozenges. ~480 PSD D50 (μm).
Mannogem 2080 has a smaller average particle size and a tighter overall particle size range. This lower particle size produces a higher surface area relative to Mannogem Granular, making it an effective API carrier system. ~320 PSD D50 (μm)
Mannogem EZ
The proprietary spray dry process used to manufacture Mannogem yields a porous material with lower disintegration times, a narrow particle size distribution, enhanced flow, and compression properties. It is due to these properties that Mannogem EZ is excellent in ODT formulations. Being a high compressibility product, it produces tablets with higher hardness than other excipients at comparable compression forces, and its higher surface area allows Mannogem EZ to work well as a base for ordered mixing with micronized APIs and low dose formulations. Designed for most DC tablets/ODT’s applications, it can be also be utilized where finer material grades are required, such as chewables, & stickpack/sachet type fills.
- Spray-dried Mannogem
- Sphericity Imparts flow
- Porosity enhances compaction
- Dry blending of micronized and low dose actives
- ~140 PSD D50 (μm)
| Products | Particle Size |
|---|---|
| Mannogem® Onyx | ~50 PSD D50 (μm) |
| Mannogem® Emerald | ~25 PSD D50 (μm) |
| Mannogem® XL | ~140 PSD D50 (μm) |
| Mannogem® Granular | ~480 PSD D50 (μm) |
| Mannogem® 2080 | ~320 PSD D50 (μm) |
| Mannogem® XL Opal | 160 µm |
| Mannogem® XL Ruby | 300 µm |
| Mannogem® EZ | ~140 PSD D50 (μm) |
| Mannogem® Powder | - |
