MIGLYOL 812 N

$0.00

Triglycerides, Medium-Chain

Product Application: Capsule,Injectables,Suspensions,Syrup,Tablet,Topical,Veterinary
Product Certification: GMP,Halal,OU Kosher
Pharmaceutical Category: Liquid lipids
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MIGLYOL 812 N is part of the C8/C10 triglyceride (MCT oil) line from IOI Oleochemical. It is a triglyceride ester of saturated coconut/palm-kernel oil derived caprylic and capric fatty acids and plant derived glycerol. MIGLYOL® 812 N is a Medium-Chain Triglycerides (ratio ~ 60:40%)

IOI is the holder of the first CEP (Certificate of suitability) ever granted for a Medium-Chain Triglyceride and has filed US-DMF Type II. MIGLYOL 812 N has been used in enteral and parenteral nutrition for decades. From a regulatory point of view, the ingredients in some of these formulations are classified as API.

MIGLYOL® 812 N has the following advantages compared to edible oils:

  • Low in impurities (as a result of production according to EU GMP guidelines)
  • High stability against oxidation
  • Liquid at 0°C

The Drug Substance version is a lipid component in parenteral nutrition. Neutral, stable, solubilizer and carrier for oil-soluble actives.

The Excipient version is a neutral, stable, penetration enhancer, drug carrier as well as solvent for oral and dermal use.

Viscosity [mPa·s] ~30 Pa·s

MIGLYOL 812 N Applications

  • Tablets, dragees: Anti-sticking, polishing agents.
  • Soft gelatine capsules: Chemically neutral, low-viscosity carrier oil, absorption promoter.
  • Drops: Carrier, solvent, and absorption promoter.
  • Suspensions, syrups: Carrier and absorption promoter for antibiotics etc.
  • Aerosol products: Carrier and solvent (glycerol trinitrate etc.).
  • Dietetic products & Nutraceuticals: Medium chain triglycerides (MCT) differ from natural fats (LCT). With regard to these essential properties: quick metabolism, not stored as body fat.
    • Physiological caloric value = 8,2 kcal/g (34,3 kJ/g) compared with LCT = 9,2 kcal/g (38,5 kJ/g).
    • Different absorption and metabolism properties: MCT is partially utilized if fat resorption disorders exist.
  • Topical therapeutics – Psoriasis Treatment and Antipruritics: Readily absorbent, scale-detaching and keratin softening oil component, particularly in combination with Vitamin A.
  • Ointments: Non-oxidizing, absorption-promoting, non-occlusive oil component with excellent spreadability.
  • Rectal products Anti-nucleating and dispersing aid for active ingredients in Hard Fat (WITEPSOL) suppositories.

MIGLYOL 812 N

 

 

 

 

 

 

 

 

 

 

 

 

Azelis Canada is a supplier of MIGLYOL and all other Pharmaceutical lines from IOI Oleochemical. Speak with your Azelis Canada representative to find the best option for your formulation!

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