Sheffield Spray Dried Fast Flo 316
D-Glucose, 4-O-β-D-galactopyranosyl-, hydrate (1:1)Product Application: Capsule filling,Powder Blend,Tablet
Product Certification: Kosher
Pharmaceutical Category: Bulking agent,Diluent,Filler,Spray Dried Monohydrate
Spray dried grades include Sheffield Spray Dried Fast Flo 316 and NF Lactose Monohydrate Sheffield Spray Dried 315 and are ideal for direct compression. Fast Flo® 316 is designed for optimal flow through high speed tablet presses.
Sheffield Spray Dried Fast Flo® 316 is recommended as an excipient, filler, diluent, and bulking agent in a wide variety of pharmaceutical tablets, capsules, powders, and other preparations. It also has applications as a nutrient and multifunctional ingredient in infant formulas, geriatric, dietetic and health foods and may be used as an ingredient in culture media.
Monohydrate Lactose is a disaccharide obtained from the whey fraction of milk and consists of one glucose and one galactose moiety. Sheffield Brand Monohydrate Lactose, N.F. Spray Dried is an optimal mixture of crystalline alpha lactose and amorphous lactose. It meets all requirements of the National Formulary as well as the European and Japanese Pharmacopeias.
- Excellent tablet hardness at low compression forces
- Eliminate wet granulation technology, reduce equipment and process validation
- Fast dissolution and low friability
- High flowability
- Low color development
Moisture Uptake of Sheffield Spray Dried Fast Flo 316
Lactose Monohydrate spray dried is typically used for direct compression. Sheffield Spray Dried Fast Flo 316 is a specially processed spray dried product with enhanced flow, compaction, and disintegration properties. The following study was performed to show an example of Fast Flo® 316 compared to other spray dried lactose.
Products Tested (all contain 1% Magnesium Stearate)
- Sheffield Spray Dried Fast Flo 316
- Spray Dried A
- Spray Dried B
Tablet hardness versus compaction force profiles for the Sheffield Spray Dried Fast Flo 316 and industry spray dried grades are shown in the below figure. Analysis of the data concluded that Fast Flo® 316 forms harder tablets at lower compaction forces relative to the typical spray dried products. Disintegration profiles for the lactose products are shown in the figure below. Analysis of the data concluded that Fast Flo® 316 forms harder tablets that have faster disintegration profiles than the other industry lactose.